Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis

Author:

Lee Choon Keong1,Zhang Shipin2,Venkatesan Gopalakrishnan1,Irsan 3,Chong Suet Yen4,Wang Jiong-Wei4ORCID,Goh Wei Jiang1,Panczyk Tomasz5ORCID,Tay Yi Zhen1,Hu Jun6,Ng Wai Kiong6,Wacker Matthias G.1,Toh Wei Seong2,Pastorin Giorgia1ORCID

Affiliation:

1. Department of Pharmacy, National University of Singapore, Science Drive 2, S15#05, Singapore 117543

2. Faculty of Dentistry, National University of Singapore, 9 Lower Kent ridge Road, Singapore 119085

3. School of Applied Science, Temasek Polytechnic, 21 Tampines Avenue 1, Singapore 529757

4. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228

5. Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, ul. Niezapominajek 8, 30239 Cracow, Poland

6. Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833

Abstract

A combination of non-ionic surfactants enhanced the released of berberine in proniosome gel and effectively reduce pain and inflammation in a mouse model of osteoarthritis.

Funder

National University of Singapore

National Research Foundation Singapore

Economic Development Board - Singapore

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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