An intramolecular hydrogen bond-promoted “green” Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity-Reference-Cited by-同舟云学术

An intramolecular hydrogen bond-promoted “green” Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity

Published:2022 Issue:51 Volume:12 Page:33175-33179
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Jie¹,Huang Jiu Hong¹,Wang Jing Ya¹,Xu Zhi Gang¹,Chen Zhong Zhu¹,Lei Jie¹^ORCID

Affiliation:

1. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China

Abstract

We report an intramolecular hydrogen bond-promoted Ugi cascade reaction for solvent-free synthesis of 2,5-diketopiperazines. Compounds (±) 5c and (±) 5e displayed potent antitumor activity against acute myeloid leukaemia and prostate cancer cell lines, respectively.

Funder

Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission

Chongqing University of Arts and Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04958A

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