Regioselective copper-catalyzed N(1)-(hetero)arylation of protected histidine-Reference-Cited by-同舟云学术

Regioselective copper-catalyzed N(1)-(hetero)arylation of protected histidine

Published:2016 Issue:38 Volume:14 Page:8937-8941
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sharma Krishna K.¹²³,Mandloi Meenakshi¹²³,Jain Rahul¹²³

Affiliation:

1. Department of Medicinal Chemistry

2. National Institute of Pharmaceutical Education and Research

3. India

Abstract

We report regioselective N(1)-arylation of protected histidine using copper(i) iodide as a catalyst, trans-N,N′-dimethylcyclohexane-1,2-diamine as a ligand and readily available aryl iodides as coupling partners under microwave irradiation at 130 °C for 40 min.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01753C

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