The hierarchies of hydrogen bonds in salts/cocrystals of isoniazid and its Schiff base

The hierarchies of hydrogen bonds in salts/cocrystals of isoniazid and its Schiff base – a case study

Published:2016 Issue:19 Volume:6 Page:15868-15876
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Oruganti Madhavi¹²³⁴⁵,Khade Pavan⁶⁷⁴⁵,Das Uttam Kumar⁸⁹¹⁰⁵,Trivedi Darshak R.¹²³⁴⁵

Affiliation:

1. Supramolecular Chemistry Laboratory

2. Department of Chemistry

3. National Institute of Technology Karnataka (NITK)-Surathkal

4. Mangalore-575 025

5. India

6. Department of Chemical Engineering

7. National Institute of Technology Karnataka (NITK) Surathkal

8. Department of Organic Chemistry

9. Indian Association for the Cultivation of Science

10. Kolkata

Abstract

A series of two salts of isoniazid and two cocrystals of its Schiff base have been synthesized and well characterized. Further, the hydrogen bonding patterns have been studied and the correlation between the bond distances and corresponding pK_a's have been deduced.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA14951G

Reference68 articles.

1. The role of cocrystals in pharmaceutical science

2. Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization

3. Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The synthesis and characterization of a series of cocrystals of an isoniazid derivative with butan-2-one and propan-2-one;Acta Crystallographica Section C Structural Chemistry;2023-08-21

2. Design of a series of cocrystals featuring isoniazid modified with diacetone alcohol;Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials;2022-11-08

3. Synthesis, structural-spectral characterization and theoretical studies of Pyridinium-4-carbohydrazide 2,4,6-trinitrophenolate;Journal of Molecular Structure;2022-08

4. Synthesis, structural-spectral characterization and density functional theoretical studies of pyridine-4-carbohydrazide bis(4-hydroxynitrobenzene);Journal of Molecular Structure;2022-01

5. Structural characterization and in-situ synthesis of quaternary ionic-cocrystal of isoniazid from un-ionized coformers;Journal of Molecular Structure;2021-06