Highly enantioselective synthesis of non-natural aliphatic α-amino acids via asymmetric hydrogenation-Reference-Cited by-同舟云学术

Highly enantioselective synthesis of non-natural aliphatic α-amino acids via asymmetric hydrogenation

Published:2015 Issue:28 Volume:13 Page:7624-7627
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ji Jianjian¹²³⁴,Chen Caiyou¹²³⁴,Cai Jiayu¹²³⁴,Wang Xinrui¹²³⁴,Zhang Kai¹²³⁴,Shi Liyang¹²³⁴,Lv Hui¹²³⁴,Zhang Xumu¹²³⁴

Affiliation:

1. Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences

2. Wuhan University

3. Wuhan

4. China

Abstract

A series of non-natural aliphatic α-amino acids were synthesized with high ee and yield by employing a rhodium–Duanphos complex as the catalyst. An efficient approach for the synthesis of the intermediate of the anti-diabetic drugs Alogliptin and Linagliptin in the DPP-4 inhibitor class was also developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01111F

Reference36 articles.

1. A practical synthesis of an HIV protease inhibitor intermediate - diastereoselective epoxide formation from chiral α-aminoaldehydes

2. Direct, highly efficient synthesis from (S)-(+)-phenylglycine of the taxol and taxotere side chains

3. Amino Acids and Their Derivatives as Stoichiometric Auxiliaries in Asymmetric Synthesis

4. New Approaches to the Use of Amino Acids as Chiral Building Blocks in Organic Synthesis[New Synthetic Methods(85)]

5. Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

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