Structural impact of GTP binding on downstream KRAS signaling-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Structural impact of GTP binding on downstream KRAS signaling

Published:2020 Issue:34 Volume:11 Page:9272-9289
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Menyhárd Dóra K.¹²³⁴⁵,Pálfy Gyula¹²³⁴⁵,Orgován Zoltán⁶⁷⁵⁸,Vida István¹²³⁴⁵,Keserű György M.⁶⁷⁵⁸^ORCID,Perczel András¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Structural Chemistry and Biology

2. MTA-ELTE Protein Modelling Research Group

3. Institute of Chemistry

4. Eötvös Loránd University

5. 1117 Budapest

6. Medicinal Chemistry Research Group

7. Research Centre for Natural Sciences

8. Hungary

Abstract

Nucleotide exchange to the physiological, activated, GTP-bound form of KRAS results in the anchoring of Tyr32 within the active site.

Funder

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

Emberi Eroforrások Minisztériuma

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC03441J

Reference84 articles.

1. An Unidentified Virus which causes the Rapid Production of Tumours in Mice

2. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

3. Drugging the undruggable RAS: Mission Possible?

4. RAS isoforms and mutations in cancer at a glance

Cited by 27 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Photonanozyme–Kras–ribosome combination treatment of non-small cell lung cancer after COVID-19;Frontiers in Immunology;2024-09-06

2. Conserved allosteric perturbation of the GTPase domains by region 1 of Ras hypervariable regions;Biophysical Journal;2024-04

3. Early pharmacological profiling of isatin derivatives as potent and selective cytotoxic agents;Biochemical Pharmacology;2024-04

4. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR;Journal of Biological Chemistry;2024-02

5. Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF3– complexes;Communications Chemistry;2024-01-31

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3