Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus-Reference-Cited by-同舟云学术

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus

Published:2019 Issue:12 Volume:17 Page:3202-3217
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Zhongxia¹²³⁴⁵^ORCID,Liu Tao¹²³⁴⁵,Wu Gaochan¹²³⁴⁵^ORCID,Kang Dongwei¹²³⁴⁵^ORCID,Fu Zhipeng¹²³⁴⁵,Wang Zhao¹²³⁴⁵,De Clercq Erik⁶⁷⁸⁹,Pannecouque Christophe⁶⁷⁸⁹,Zhan Peng¹²³⁴⁵,Liu Xinyong¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology (Ministry of Education)

3. School of Pharmaceutical Sciences

4. Shandong University

5. 250012 Jinan

6. Rega Institute for Medical Research

7. K.U. Leuven

8. B-3000 Leuven

9. Belgium

Abstract

Novel 1,2,3-triazole-derived diarylpyrimidines were discovered as potent HIV-1 NNRTIs.

Funder

National Natural Science Foundation of China

Shandong University

Department of Science and Technology of Shandong Province

KU Leuven

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00032A

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