The MRD disk: automated minimal residual disease monitoring by highly sensitive centrifugal microfluidic multiplex qPCR-Reference-Cited by-同舟云学术

The MRD disk: automated minimal residual disease monitoring by highly sensitive centrifugal microfluidic multiplex qPCR

Published:2021 Issue:3 Volume:21 Page:558-570
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Juelg Peter¹²³^ORCID,Kipf Elena¹²³,Specht Mara¹²³,Fillies Marion⁴⁵³,Eckert Cornelia⁴⁵³,Paust Nils¹²³⁶⁷^ORCID,Zengerle Roland¹²³⁶⁷,Lehnert Michael¹²³^ORCID,Hutzenlaub Tobias¹²³⁶⁷

Affiliation:

1. Hahn-Schickard

2. 79110 Freiburg

3. Germany

4. Charité – Universitätsmedizin Berlin

5. 13353 Berlin

6. Laboratory for MEMS Applications

7. IMTEK – Department of Microsystems Engineering

Abstract

A centrifugal microfluidic system for automated, highly sensitive and multiplexed qPCR analyses, demonstrated for minimal residual disease monitoring in acute lymphoblastic leukaemia.

Funder

Bundesministerium für Bildung und Forschung

Ministerium für Wirtschaft, Arbeit und Wohnungsbau Baden-Württemberg

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D0LC00945H

Reference37 articles.

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3. Acute lymphoblastic leukemia: a comprehensive review and 2017 update

4. Improving the outcome for children with cancer: Development of targeted new agents

5. Minimal residual disease (MRD) status prior to allogeneic stem cell transplantation is a powerful predictor for post-transplant outcome in children with ALL

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