Selective electrophilic di- and monofluorinations for the synthesis of 4-difluoromethyl and 4-fluoromethyl quinazolin(thi)ones by a Selectfluor-triggered multi-component reaction-Reference-Cited by-同舟云学术

Selective electrophilic di- and monofluorinations for the synthesis of 4-difluoromethyl and 4-fluoromethyl quinazolin(thi)ones by a Selectfluor-triggered multi-component reaction

Published:2022 Issue:6 Volume:9 Page:1567-1573
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Ruiqin¹²,Ma Renchao¹,Fu Qinjiao¹,Chen Rener¹,Wang Zhiming¹^ORCID,Wang Lei¹^ORCID,Ma Yongmin¹²^ORCID

Affiliation:

1. Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang, Zhejiang, 318000, P. R. China

2. School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, P R China

Abstract

A simple and efficient domino protocol for the selective synthesis of gem-difluoro-oxylated and monofluoro-oxylated quinazolin(thi)ones from readily available starting materials mediated by Selectfluor was established.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01728D

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5. Iodine‐Catalyzed Double [4+2] Oxidative Annulations for the Synthesis of Bipyrazines from Ketones and Diamines by a Domino Strategy

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