Superparamagnetic core–shell electrospun scaffolds with sustained release of IONPs facilitating in vitro and in vivo bone regeneration

Author:

Hu Shuying1,Chen Hanbang1,Zhou Fang1,Liu Jun1,Qian Yunzhu2,Hu Ke3,Yan Jia1,Gu Zhuxiao4,Guo Zhaobin5,Zhang Feimin1ORCID,Gu Ning6

Affiliation:

1. Jiangsu Province Key Laboratory of Oral Diseases, Department of Prosthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China

2. Center of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

3. Laboratory of Oral Regenerative Medicine Technology, School of Biomedical Engineering and Informatics, Department of Biomedical Engineering, Nanjing Medical University, Nanjing 210000, China

4. Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics, Southeast University, Nanjing 211189, China

5. Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, 21218, USA

6. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China

Abstract

Core–shell electrospun scaffolds with γ-Fe2O3 encapsulation were first fabricated with enhanced physical and mechanical properties, and could promote osteogenic differentiation of rADSCs and in vivo bone regeneration.

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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