Selection of optimised ligands by fluorescence-activated bead sorting-Reference-Cited by-同舟云学术

Selection of optimised ligands by fluorescence-activated bead sorting

Published:2023 Issue:35 Volume:14 Page:9517-9525
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Paul Alexandra R.¹^ORCID,Falsaperna Mario¹,Lavender Helen²,Garrett Michelle D.³^ORCID,Serpell Christopher J.¹⁴^ORCID

Affiliation:

1. School of Chemistry and Forensic Sciences, Division of Natural Sciences, University of Kent, Canterbury, CT2 7NH, UK

2. Avvinity Therapeutics, 66 Prescot Street, London, E1 8NN, UK

3. School of Biosciences, Division of Natural Sciences, University of Kent, Canterbury, CT2 7NJ, UK

4. School of Pharmacy, University College London, London, WC1N 1AX, UK

Abstract

Chemical modifications improve aptamer properties, but it has been challenging to work out the best modifications out of all the possibilities. We present an automated bead-based system for selecting the best locations and types of chemical modifications to improve the affinity of aptamers.

Funder

University of Kent

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03581F

Reference61 articles.

1. Analysis of aptamer discovery and technology

2. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer

3. RNA Aptamers Directed Against Oligosaccharides

4. Selection of Aptamers against Live Bacterial Cells

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