Employing LiCl salt gradient in the wild-type α-hemolysin nanopore to slow down DNA translocation and detect methylated cytosine-Reference-Cited by-同舟云学术

Employing LiCl salt gradient in the wild-type α-hemolysin nanopore to slow down DNA translocation and detect methylated cytosine

Published:2019 Issue:21 Volume:11 Page:10536-10545
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Vu Trang¹²³⁴,Borgesi Julia¹²³⁴,Soyring Joanna¹²³⁴,D'Alia Melissa¹²³⁴,Davidson Shanna-Leigh¹²³⁴,Shim Jiwook¹²³⁴^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Rowan University

3. Glassboro

4. USA

Abstract

In this research, we demonstrate a label-free detection, biological nanopore-based method to distinguish methylated cytosine (mC) from naked cytosine (C) in sample mixtures containing both C and mC at a prolonged translocation duration.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NR/C9NR00502A

Reference73 articles.

1. DNA methylation biomarkers in cancer: progress towards clinical implementation

2. Nanopore-Based Assay for Detection of Methylation in Double-Stranded DNA Fragments

3. A genetic model for colorectal tumorigenesis

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