Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway

Author:

Yu Xiaomin12,Zhang Yejia1,Pei Ke1,Tan Junjun1,Tian Huizhen1,Xu Tian1,Liu Fadi3,Peng Nanqin1,Huang Yilin1,Huang Xinying4,Huang Xinlei4,Wu Jianfeng1,Liu Qiong12,Zeng Lingbing1,Hua Wei5ORCID,Huang Xiaotian1ORCID

Affiliation:

1. The First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China, 330006

2. Medical Experimental teaching center, School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China, 330006

3. Jiangxi Provincal Children's Hospital, Nanchang, China, 330006

4. The First Clinical Medical School, Gannan Medical University, Ganzhou, China, 341000

5. Jiangxi-Oai Joint Research Institute, Nanchang University, Nanchang, China, 330047

Abstract

L. plantarum FLPL05 attenuates CVB3-induced pancreatic cells apoptosis through the BAX/BCL-2/CASP3 signaling pathway and inhibits the release of inflammatory cytokines (e.g. IL-1β, IL-6, and TNF-α).

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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