TetraPh-Tol-BITIOPO: a new atropisomeric 3,3′-bithiophene based phosphine oxide as an organocatalyst in Lewis base-catalyzed Lewis acid mediated reactions

Author:

Mirco Abbinante Vincenzo123,Maurizio Benaglia4563ORCID,Sergio Rossi4563,Tiziana Benincori123ORCID,Roberto Cirilli7893,Marco Pierini1011123ORCID

Affiliation:

1. Dipartimento di Scienza ed Alta Tecnologia dell'Università dell'Insubria

2. 22100 Como

3. Italy

4. Dipartimento di Chimica

5. Università degli Studi di Milano

6. 20133 Milano

7. Centro Nazionale per il Controllo e la Valutazione dei Farmaci

8. Istituto Superiore di Sanità

9. 00161 Roma

10. Dipartimento di Chimica e Tecnologie del Farmaco

11. Università degli Studi di Roma “La Sapienza”

12. 00185 Roma

Abstract

A new chiral phosphine oxide based on a 3,3′-bithiophene scaffold (TetraPh-Tol-BITIOPO) was synthesized, fully characterized and separated into antipodes through chiral HPLC.

Funder

Sapienza Università di Roma

Università degli Studi di Milano

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference64 articles.

1. Lewis Base Catalysis in Organic Synthesis

2. R. J. P. Corriu , J. C.Young , D. A.Armitage , R. J. P.Corriu , T. C.Kendrick , B.Parbhoo , T. D.Tilley , J. W.White and J. C.Young , in The Silicon–Heteroatom Bond , John Wiley & Sons, Inc , 1991 , pp. 1–48

3. J. Wagler , U.Böhme and E.Kroke , Higher-Coordinated Molecular Silicon Compounds , Springer , 2013 , vol. 155 , p. 29

4. S. E. Denmark and G. L.Beutner , Principles, Definitions, Terminology, and Orbital Analysis of Lewis Base-Lewis Acid Interactions Leading to Catalysis , in Lewis Base Catalysis in Organic Synthesis , Wiley-VCH Verlag GmbH & Co. KGaA , 2016 , p. 31

5. S. Rossi and S. E.Denmark , Lewis Base-Catalyzed, Lewis Acid-Mediated Reactions (n → σ*) , in Lewis Base Catalysis in Organic Synthesis , Wiley-VCH Verlag GmbH & Co. KGaA , 2016 , p. 1039

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