Natural products with therapeutic potential in melanoma metastasis

Author:

AlQathama A.12345,Prieto J. M.1234

Affiliation:

1. Department of Pharmaceutical and Biological Chemistry

2. UCL School of Pharmacy

3. WC1N 1AX London

4. UK

5. Department of Pharmacognosy

Abstract

Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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