Natural products with therapeutic potential in melanoma metastasis
Author:
Affiliation:
1. Department of Pharmaceutical and Biological Chemistry
2. UCL School of Pharmacy
3. WC1N 1AX London
4. UK
5. Department of Pharmacognosy
Abstract
Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/NP/C4NP00130C
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