Interspecies differences in stability kinetics and plasma esterases involved in hydrolytic activation of curcumin diethyl disuccinate, a prodrug of curcumin-Reference-Cited by-同舟云学术

Interspecies differences in stability kinetics and plasma esterases involved in hydrolytic activation of curcumin diethyl disuccinate, a prodrug of curcumin

Published:2019 Issue:8 Volume:9 Page:4626-4634
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ratnatilaka Na Bhuket Pahweenvaj¹²³⁴⁵^ORCID,Jithavech Ponsiree⁶⁴⁵⁷^ORCID,Ongpipattanakul Boonsri²³⁴⁵⁷,Rojsitthisak Pornchai⁶⁴⁵⁷⁸^ORCID

Affiliation:

1. Biomedicinal Chemistry Program

2. Department of Biochemistry and Microbiology

3. Faculty of Pharmaceutical Sciences

4. Chulalongkorn University

5. Bangkok

6. Natural Products for Ageing and Chronic Diseases Research Unit

7. Thailand

8. Department of Food and Pharmaceutical Chemistry

Abstract

Curcumin diethyl disuccinate is metabolized at different rates and hydrolyzed by different esterases in rat, dog and human plasma.

Funder

Chulalongkorn University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA08594C

Reference39 articles.

1. Antioxidant and radical scavenging properties of curcumin

2. Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

3. Stability of curcumin in buffer solutions and characterization of its degradation products

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