Rapid construction of tetrahydropyridine scaffolds via formal imino Diels–Alder reactions of Schiff bases and Nazarov reagents-Reference-Cited by-同舟云学术

Rapid construction of tetrahydropyridine scaffolds via formal imino Diels–Alder reactions of Schiff bases and Nazarov reagents

Published:2019 Issue:39 Volume:17 Page:8827-8831
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Yen-Ku¹²³⁴⁵^ORCID,Rawal Viresh H.⁶⁷⁸⁹^ORCID

Affiliation:

1. Department of Applied Chemistry

2. National Chiao Tung University

3. 1001 University Road

4. Hsinchu 30010

5. Taiwan

6. Department of Chemistry

7. University of Chicago

8. Chicago

9. USA

Abstract

A collection of piperidine derivatives including tetrabenazine was synthesized via aza-annulation of Nazarov reagents and Schiff bases in protic solvents.

Funder

National Science Foundation

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01880H

Reference38 articles.

1. Exploring biology with small organic molecules

2. Organic synthesis toward small-molecule probes and drugs

3. Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework

4. The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures

5. Privileged scaffolds for library design and drug discovery

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