Allosteric inhibition of α-thrombin enzymatic activity with ultrasmall gold nanoparticles
Author:
Affiliation:
1. Department of Biochemistry
2. Federal University of São Paulo
3. São Paulo
4. Brazil
5. National Institute of Biomedical Imaging and Bioengineering
6. National Institutes of Health
7. Bethesda
8. USA
Abstract
The enzymatic activity of α-thrombin was allosterically regulated by interactions with ultrasmall gold nanoparticles.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
National Institute of Biomedical Imaging and Bioengineering
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NA/C8NA00081F
Reference86 articles.
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2. The Different Ways through Which Specificity Works in Orthosteric and Allosteric Drugs
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4. Allostery in Disease and in Drug Discovery
5. Probing enzyme-nanoparticle interactions using combinatorial gold nanoparticle libraries
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