Palladium(ii) complexes bearing 1-iminothiolate-3,5-dimethylpyrazoles: synthesis, cytotoxicity, DNA binding and enzymatic inhibition studies-Reference-Cited by-同舟云学术

Palladium(ii) complexes bearing 1-iminothiolate-3,5-dimethylpyrazoles: synthesis, cytotoxicity, DNA binding and enzymatic inhibition studies

Published:2020 Issue:45 Volume:44 Page:19891-19901
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

de Moura Thales Reggiani¹²³⁴⁵^ORCID,Zanetti Renan Diego¹²³⁴⁵,Silva Debora Eduarda Soares¹²³⁴⁵^ORCID,de Farias Renan Lira¹²³⁴⁵^ORCID,Mauro Antonio Eduardo¹²³⁴⁵,Pereira José Clayston Melo¹²³⁴⁵,de Souza Aline Aparecida⁶⁷⁸⁵,da Silva Siqueira Fábio⁶⁷⁸⁵,de Souza Júdice Wagner Alves⁶⁷⁸⁵^ORCID,Lima Mauro Almeida⁹¹⁰¹¹⁵,Rocha Fillipe Vieira⁹¹⁰¹¹⁵,Deflon Victor Marcelo¹²¹³¹¹⁵^ORCID,Vieira de Godoy Netto Adelino¹²³⁴⁵^ORCID

Affiliation:

1. UNESP – Univ. Estadual Paulista

2. Instituto de Química

3. Departamento de Química Geral e Inorgânica

4. Araraquara

5. Brazil

6. UMC - Univ. de Mogi das Cruzes

7. Centro Interdisciplinar de Investigação Bioquímica

8. Mogi das Cruzes

9. UFSCar – Univ. Federal de São Carlos

10. Departamento de Química

11. São Carlos

12. USP – Univ. de São Paulo

13. Instituto de Química de São Carlos

Abstract

This work describes the enzymatic inhibitory activity of four novel Pd(ii) complexes towards topoisomerase IIα and cathepsins B and L.In silicostudies agree well with the enhancedin vitrocathepsin B inhibition induced by compound4(58% at 10 μM).

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ02825H

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1. Metal complexes in cancer therapy – an update from drug design perspective