Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria-Reference-Cited by-同舟云学术

Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria

Published:2014 Issue:20 Volume:50 Page:2667-2669
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Zhao Linhong¹²³⁴⁵,Cheng Qinqin¹²³⁴⁵,Wang Zhen¹²³⁴⁵,Xi Zhaoyong¹²³⁴⁵,Xu Dechen¹²³⁴⁵,Liu Yangzhong¹²³⁴⁵

Affiliation:

1. CAS Key Laboratory of Soft Matter Chemistry

2. CAS High Magnetic Field Laboratory

3. Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology

4. University of Science and Technology of China

5. Hefei Anhui, China

Abstract

Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C3CC48847K

Reference32 articles.

1. Structure, Recognition, and Processing of Cisplatin−DNA Adducts

2. Cisplatin: mode of cytotoxic action and molecular basis of resistance

3. Molecular mechanisms of cisplatin resistance

4. Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?

5. Cisplatin resistance: Preclinical findings and clinical implications

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