Synthesis of maleimide-based enediynes with cyclopropane moieties for enhanced cytotoxicity under normoxic and hypoxic conditions-Reference-Cited by-同舟云学术

Synthesis of maleimide-based enediynes with cyclopropane moieties for enhanced cytotoxicity under normoxic and hypoxic conditions

Published:2021 Issue:22 Volume:9 Page:4502-4509
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Wang Wenbo¹²³⁴⁵,Lu Haotian¹²³⁴⁵,Zhang Mengsi¹²³⁴⁵,Ma Hailong¹²³⁴⁵,Cheng Xiaoyu¹²³⁴⁵,Ding Yun¹²³⁴⁵^ORCID,Hu Aiguo¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Advanced Polymeric Materials

2. School of Materials Science and Engineering

3. East China University of Science and Technology

4. Shanghai 200237

5. China

Abstract

Maleimide-based enediynes with cyclopropane moieties show enhanced radical character by taking advantage of radical clock reactions. They are highly effecient antitumor agents under both normoxic and hypoxic conditions.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Shanghai Leading Academic Discipline Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D1TB00142F

Reference57 articles.

1. Calicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1I

2. Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit.

3. Esperamicins, a novel class of potent antitumor antibiotics. 2. Structure of esperamicin X

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Caged xanthone derivatives to promote mitochondria-mediated apoptosis in breast cancer cells;Bioorganic & Medicinal Chemistry;2024-04

2. Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus;CCS Chemistry;2024-02-03

3. Extracellular Disintegration of ViralProteins as an Innovative Strategyfor Developing Broad-SpectrumAntivirals Against Coronavirus;CCS CHEM;2024

4. Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery;Chemical Science;2024

5. Synthesis, Reaction Mechanism, DNA Cleavage and Antitumor Properties of Naphthoquinone‐Based Enediynes;Asian Journal of Organic Chemistry;2023-07-19