Covalent cannabinoid receptor ligands – structural insight and selectivity challenges-Reference-Cited by-同舟云学术

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Covalent cannabinoid receptor ligands – structural insight and selectivity challenges

Published:2022 Issue:5 Volume:13 Page:497-510
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Liddle Ian¹^ORCID,Glass Michelle²^ORCID,Tyndall Joel D. A.³^ORCID,Vernall Andrea J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Otago, Dunedin, New Zealand

2. Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand

3. School of Pharmacy, University of Otago, Dunedin, New Zealand

Abstract

X-ray crystallography and cryogenic electronic microscopy have provided significant advancement in the knowledge of GPCR structure and have allowed the rational design of covalent GPCR ligands.

Funder

University of Otago

Maurice Wilkins Centre for Molecular Biodiscovery

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00006G

Reference92 articles.

1. Mechanisms of signalling and biased agonism in G protein-coupled receptors

2. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

3. Understanding Functional Residues of the Cannabinoid CB1 Receptor for Drug Discovery

4. Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands

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