Molecular mechanics of coiled coils loaded in the shear geometry

Author:

Goktas Melis1234,Luo Chuanfu1534,Sullan Ruby May A.1234ORCID,Bergues-Pupo Ana E.1534,Lipowsky Reinhard1534ORCID,Vila Verde Ana1534ORCID,Blank Kerstin G.1234ORCID

Affiliation:

1. Max Planck Institute of Colloids and Interfaces

2. Mechano(bio)chemistry

3. 14424 Potsdam

4. Germany

5. Department of Theory & Bio-Systems

Abstract

Shearing of short, dimeric coiled coils proceedsviathree competing timescale-dependent mechanisms: progressive helix uncoiling, uncoiling-assisted sliding and dissociation.

Funder

Max-Planck-Gesellschaft

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference75 articles.

1. Comparing function and structure between entire proteomes

2. Coiled Coil Domains: Stability, Specificity, and Biological Implications

3. D. N. Woolfson , in Adv. Protein Chem. , Academic Press , 2005 , vol. 70 , pp. 79–112

4. A. N. Lupas and M.Gruber , in Adv. Protein Chem. , Academic Press , 2005 , vol. 70 , pp. 37–38

5. Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials

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