Polymer–DNA assembled nanoflower for targeted delivery of dolastatin-derived microtubule inhibitors

Author:

Wu Tiantian12ORCID,Shi Yanqiang1,Yang Tao2,Zhao Pengxuan2,Yang Zhu34,Yang Bin1

Affiliation:

1. Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou 510091, China

2. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China

3. Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China,

4. Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350212, China

Abstract

Polymer–DNA assembled nanoflower for targeted delivery of dolastatin-derived microtubule inhibitors was developed, and it exhibited increased cellular uptake and enhanced inhibitory effect, especially in multidrug-resistant tumor cell.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hainan Province

Major Science and Technology Project of Hainan Province

Publisher

Royal Society of Chemistry (RSC)

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