Late-stage functionalisation of alkyne-modified phospha-xanthene dyes: lysosomal imaging using an off–on–off type of pH probe
Author:
Affiliation:
1. Department of Chemistry
2. Graduate School of Science
3. Integrated Research Consortium on Chemical Sciences (IRCCS)
4. Nagoya University
5. Nagoya 464-8602
6. Institute of Transformative Bio-Molecules (WPI-ITbM)
7. Nagoya 464-8601
8. Japan
Abstract
A series of NIR-emissive phospha-xanthene dyes bearing an ethynyl group are reported. The late-stage functionalisation of the NIR dyes enables creation of multi-functionalised fluorescent probes that can be designed to target organelles of interest.
Funder
Japan Society for the Promotion of Science
Mitsubishi Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01705E
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