Exchangeable proton ENDOR as a probe of the redox-active iron center in activated bleomycin and ferric bleomycin-Reference-Cited by-同舟云学术

Exchangeable proton ENDOR as a probe of the redox-active iron center in activated bleomycin and ferric bleomycin

Published:2017 Issue:39 Volume:46 Page:13263-13272
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Burger Richard M.¹²,Grigoryants Vladimir M.³⁴⁵²,Scholes Charles P.³⁴⁵²^ORCID

Affiliation:

1. Astoria

2. USA

3. Department of Chemistry

4. University at Albany

5. Albany

Abstract

This work establishes the existence of and implies the mechanistic role of specific exchangeable protons near the Fe(iii) of activated bleomycin (ABLM).

Funder

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT01354J

Reference47 articles.

1. Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal

2. Iron Coordination of Activated Bleomycin Probed by Q- and X-Band ENDOR: Hyperfine Coupling to Activated 17O Oxygen, 14N, and Exchangeable 1H

3. Electronic Structure of Activated Bleomycin: Oxygen Intermediates in Heme versus Non-Heme Iron

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