Phosphine-catalyzed [3 + 2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonene-1,3-diones-Reference-Cited by-同舟云学术

Phosphine-catalyzed [3 + 2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonene-1,3-diones

Published:2017 Issue:36 Volume:15 Page:7523-7526
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Luo Wenjun¹²³⁴⁵,Hu Haiwen¹²³⁴⁵,Nian Sanfei¹²³⁴⁵,Qi Liang¹²³⁴⁵,Ling Fei¹²³⁴⁵,Zhong Weihui¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education

2. College of Pharmaceutical Sciences

3. Zhejiang University of Technology

4. Hangzhou 310014

5. P R China

Abstract

A novel method for phosphine-catalyzed [3 + 2] annulation of γ-substituted allenoates with succinimides was developed, which was successfully applied to the synthesis of 2-azaspiro[4.4]nonene-1,3-diones derivatives in 50–96% yield, with high regio- and diastereoselectivities.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01957B

Reference49 articles.

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4. Phosphine-Catalyzed Annulations of 4,4-Dicyano-2-Methylenebut-3-enoates with Maleimides and Maleic Anhydride

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