Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of heat stable antifungal factor (HSAF)-Reference-Cited by-同舟云学术

Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of heat stable antifungal factor (HSAF)

Published:2015 Issue:15 Volume:5 Page:11644-11648
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Olson Andrew S.¹²³⁴,Chen Haotong¹²³⁴,Du Liangcheng¹²³⁴,Dussault Patrick H.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Nebraska-Lincoln

3. Lincoln

4. USA

Abstract

The N-acetylcystamine thioester of dodecapentaenoic acid is synthesized. The thioester is investigated as a biosynthetic substrate and was not incorporated in the observed products.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA14829K

Reference23 articles.

1. Biosynthesis of HSAF, a Tetramic Acid-Containing Macrolactam from Lysobacter enzymogenes

2. Further reactions of t-butyl 3-oxobutanthioate and t-butyl 4-diethyl-phosphono-3-oxobutanthioate : Carbonyl coupling reactions, amination, use in the preparation of 3-acyltetramic acids and application to the total synthesis of fuligorubin A.

3. Oxo Polyene Macrolide Antibiotics

4. Recent Applications of the Horner-Wadsworth-Emmons Reaction to the Synthesis of Natural Products

5. Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis

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