Study of the Pauson–Khand reaction in flow over alkynylphenyl vinyl ethers: towards the synthesis of tricyclic multisubstituted benzofurans

Author:

García-Lacuna Jorge1ORCID,Alonso Maialen1,Domínguez Gema1,Pérez Castells Javier1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Madrid, Spain

Abstract

Flow methodology allows the first efficient and scalable catalytic Pauson–Khand reaction of vinyl ethers. Cycopenta-benzofuranones are produced.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference31 articles.

1. G.Domínguez and J.Pérez-Castells , in Science Of Synthesis: Metal-Catalyzed Cyclization Reactions , ed. S. Ma , Thieme Chem , 2017 , vol. 2 , p. 99

2. The Pauson-Khand Reaction: Scope, Variations and Applications , ed. R. R. Torres , Wiley , Hoboken NJ , 2012

3. A Decade of Advancements in Pauson–Khand‐Type Reactions

4. A catalytic scalable Pauson–Khand reaction in a plug flow reactor

5. Synthesis of treprostinil: key Claisen rearrangement and catalytic Pauson–Khand reactions in continuous flow

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