Facile difluoromethylation of aliphatic alcohols with an S-(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study-Reference-Cited by-同舟云学术

Facile difluoromethylation of aliphatic alcohols with an S-(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study

Published:2019 Issue:52 Volume:55 Page:7446-7449
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Guo-Kai¹²³⁴⁵^ORCID,Li Xin¹²³⁴⁵,Qin Wen-Bing¹²³⁴⁵,Peng Xiao-Shui⁶⁷⁸⁵^ORCID,Wong Henry N. C.⁶⁷⁸⁵^ORCID,Zhang Linxing⁹¹⁰¹¹⁵^ORCID,Zhang Xinhao⁹¹⁰¹¹⁵^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Shenzhen University Health Science Centre

3. Shenzhen University

4. Shenzhen 518060

5. China

6. Department of Chemistry

7. the Chinese University of Hong Kong

8. Shatin

9. Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics

10. Peking University Shenzhen Graduate School

11. Shenzhen 518055

Abstract

Facile difluoromethylation of alcohols is herein described, and the mechanistic study reveals that the difluorocarbene pathway is rational via a five-membered transition state with the participation of water.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC03487K

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2. Analytical Methods for the Determination in Soil of Herbicides Used in Forestry by GC−NPD and GC/MS

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