Post cross-linked ROS-responsive poly(β-amino ester)-plasmid polyplex NPs for gene therapy of EBV-associated nasopharyngeal carcinoma-Reference-Cited by-同舟云学术

Post cross-linked ROS-responsive poly(β-amino ester)-plasmid polyplex NPs for gene therapy of EBV-associated nasopharyngeal carcinoma

Published:2024 Issue:12 Volume:12 Page:3129-3143
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Yuan Caiyan¹²,Chang Shuangyan³,Zhang Chong¹,Dong Dirong³,Ding Jiahui¹,Mahdavian Ali Reza⁴^ORCID,Hu Zheng³,Sun Lili³,Tan Songwei¹^ORCID

Affiliation:

1. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

2. The First Hospital of Nanchang, Nanchang 330008, China

3. Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Donghu 169th Road, Wuchang District, Wuhan 430062, Hubei, China

4. Polymer Science Department, Iran Polymer and Petrochemical Institute, Tehran 14967, Iran

Abstract

Post cross-linked ROS-responsive P-aP-DTT-pDNA polyplex NPs could effectively transfect CRISPR/Cas9 encoded plasmids into nasopharyngeal carcinoma (NPC) cells and targeted cleavage of the Lmp1 oncogene to achieve gene therapy of NPC.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02926C

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