An electrochemical biosensor exploiting binding-induced changes in electron transfer of electrode-attached DNA origami to detect hundred nanometer-scale targets

Author:

Arroyo-Currás Netzahualcóyotl1234ORCID,Sadeia Muaz5674,Ng Alexander K.5674,Fyodorova Yekaterina5674ORCID,Williams Natalie5674,Afif Tammy5674,Huang Chao-Min89104,Ogden Nathan111213144,Andresen Eguiluz Roberto C.111213144ORCID,Su Hai-Jun89104ORCID,Castro Carlos E.89104ORCID,Plaxco Kevin W.111213144ORCID,Lukeman Philip S.5674ORCID

Affiliation:

1. Department of Pharmacology and Molecular Sciences

2. Johns Hopkins University School of Medicine

3. Baltimore

4. USA

5. Department of Chemistry

6. St. John's University

7. Queens

8. Department of Mechanical and Aerospace Engineering/Biophysics Graduate Program

9. The Ohio State University

10. Columbus

11. Department of Chemistry and Biochemistry

12. Center for Bioengineering and Department of Chemical Engineering

13. University of California Santa Barbara

14. Santa Barbara

Abstract

Using DNA origami as the recognition element in an electrochemical biosensor enables the selective and direct detection of “mesoscale” virus-sized analytes.

Funder

Army Research Office

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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