High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening-Reference-Cited by-同舟云学术

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High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Published:2018 Issue:12 Volume:9 Page:3192-3199
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Qin Shanshan¹²³⁴,Meng Mengmeng⁵⁶⁷⁴,Yang Dehua⁸⁹¹⁰¹¹³,Bai Wenwen⁵⁶⁷⁴,Lu Yan¹²³⁴¹²,Peng Yao¹²³⁴,Song Gaojie¹²³⁴,Wu Yiran¹²³⁴,Zhou Qingtong¹²³⁴,Zhao Suwen¹²³⁴¹²,Huang Xiping¹³¹⁴¹⁵¹⁶¹⁷,McCorvy John D.¹³¹⁴¹⁵¹⁶¹⁷,Cai Xiaoqing⁸⁹¹⁰¹¹³,Dai Antao⁸⁹¹⁰¹¹³,Roth Bryan L.¹³¹⁴¹⁵¹⁶¹⁷,Hanson Michael A.¹⁸¹⁹¹⁷,Liu Zhi-Jie¹²³⁴¹²,Wang Ming-Wei⁸⁹¹⁰¹¹³,Stevens Raymond C.¹²³⁴¹²,Shui Wenqing¹²³⁴¹²^ORCID

Affiliation:

1. iHuman Institute

2. ShanghaiTech University

3. Shanghai

4. China

5. College of Pharmacy

6. Nankai University

7. Tianjin

8. The National Center for Drug Screening

9. The CAS Key Laboratory of Receptor Research

10. Shanghai Institute of Materia Medica

11. Chinese Academy of Sciences

12. School of Life Science and Technology

13. Department of Pharmacology

14. Chapel Hill School of Medicine

15. University of North Carolina

16. NC 27599 Chapel Hill

17. USA

18. GPCR Consortium

19. CA92078 San Marcos

Abstract

High-throughput identification of GPCR modulators through affinity MS screening.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

National Health and Family Planning Commission of the People's Republic of China

Natural Science Foundation of Shanghai

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04698G

Reference28 articles.

1. Structural diversity of G protein-coupled receptors and significance for drug discovery

2. A comprehensive map of molecular drug targets

3. An update of novel screening methods for GPCR in drug discovery

4. Emerging Approaches to GPCR Ligand Screening for Drug Discovery

5. Design and Use of Fluorescent Ligands to Study Ligand–Receptor Interactions in Single Living Cells

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