Insights into the role of electrostatics in temperature adaptation: a comparative study of psychrophilic, mesophilic, and thermophilic subtilisin-like serine proteases-Reference-Cited by-同舟云学术

Insights into the role of electrostatics in temperature adaptation: a comparative study of psychrophilic, mesophilic, and thermophilic subtilisin-like serine proteases

Published:2018 Issue:52 Volume:8 Page:29698-29713
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xia Yuan-Ling¹²³⁴,Sun Jian-Hong¹²³⁴,Ai Shi-Meng⁵⁶³⁴,Li Yi¹²³⁴,Du Xing¹²³⁴,Sang Peng⁷⁸⁹⁴^ORCID,Yang Li-Quan⁷⁸⁹⁴,Fu Yun-Xin¹²³⁴¹⁰,Liu Shu-Qun¹²³⁴¹¹^ORCID

Affiliation:

1. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan

2. Yunnan University

3. Kunming

4. P. R. China

5. Department of Applied Mathematics

6. Yunnan Agricultural University

7. College of Agriculture and Biological Science

8. Dali University

9. Dali

10. Human Genetics Center and Division of Biostatistics

11. Key Laboratory for Tumor Molecular Biology of High Education in Yunnan Province

Abstract

Differently charged surface patches contribute to temperature adaptation of subtilisin-like serine proteases through affecting/modulating the protein solubility and thermostability and the structural flexibility/rigidity/stability.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA05845H

Reference74 articles.

1. How do thermophilic proteins deal with heat?

2. Thermophilic Adaptation of Proteins

3. Activity-Stability Relationships in Extremophilic Enzymes