Design, synthesis and structure–activity relationship studies on erianin analogues as pyruvate carboxylase inhibitors in hepatocellular carcinoma cells-Reference-Cited by-同舟云学术

Design, synthesis and structure–activity relationship studies on erianin analogues as pyruvate carboxylase inhibitors in hepatocellular carcinoma cells

Published:2023 Issue:34 Volume:21 Page:7005-7017
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shi Hailong¹²³,Yang Jinlian¹²³,Qiao Zeen¹²,Li Lingyu¹²,Liu Gang¹²,Dai Qi³,Xu Li³,Jiao Wei¹^ORCID,Zhang Guolin¹,Wang Fei¹,Lu Xiaoxia¹³,Ma Xiaofeng¹^ORCID

Affiliation:

1. Natural Product Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, P. R. China

2. University of Chinese Academy of Sciences Institution Chinese Academy of Sciences Beijing, 100049, P. R. China

3. NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), P. R. China

Abstract

A total of 47 erianin analogues were designed, synthesized, and evaluated as pyruvate carboxylase inhibitors, two of which showed higher activity, better chemical stability, and higher log P values than erianin itself.

Funder

National Natural Science Foundation of China

Chengdu Institute of Biology

Chinese Academy of Sciences

Sichuan Province Science and Technology Support Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01114C

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1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

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4. Risk Factors, Prognosis, and Management of Early and Late Intrahepatic Recurrence After Resection of Primary Clear Cell Carcinoma of the Liver

5. Treatment Efficacy Differences of Sorafenib for Advanced Hepatocellular Carcinoma: A Meta-Analysis of Randomized Clinical Trials

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