In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis-Reference-Cited by-同舟云学术

In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis

Published:2015 Issue:8 Volume:6 Page:5076-5085
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sucipto H.¹²³⁴,Sahner J. H.⁵²⁶⁷³,Prusov E.⁸⁹⁴,Wenzel S. C.¹²³⁴,Hartmann R. W.⁵²⁶⁷³,Koehnke J.¹⁰²³⁴,Müller R.¹²³⁴

Affiliation:

1. Department of Microbial Natural Products

2. Helmholtz Institute for Pharmaceutical Research Saarland

3. 66123 Saarbrücken

4. Germany

5. Department of Drug Design and Optimization

6. Pharmaceutical and Medicinal Chemistry

7. Saarland University

8. Helmholtz Centre for Infection Research

9. 38124 Braunschweig

10. Workgroup Structural Biology of Biosynthetic Enzymes

Abstract

α-Pyrone rings exist in many polyketide synthase (PKS) derived natural products. We report the first in vitro reconstitution of α-pyrone ring formation by a type I PKS using chemically synthesized substrates.

Funder

Wellcome Trust

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC01013F

Reference34 articles.

1. Novel classes of antibiotics or more of the same?

2. Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now

3. Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry

4. A brief tour of myxobacterial secondary metabolism

5. The Biosynthetic Logic of Polyketide Diversity

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