Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIα and Aurora B-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIα and Aurora B

Published:2016 Issue:49 Volume:6 Page:42794-42806
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Januchta Wioleta¹²³⁴⁵,Serocki Marcin⁶⁷³⁴⁵,Dzierzbicka Krystyna¹²³⁴⁵,Cholewinski Grzegorz¹²³⁴⁵,Gensicka Monika¹²³⁴⁵,Skladanowski Andrzej⁶⁷³⁴⁵

Affiliation:

1. Department of Organic Chemistry

2. Chemical Faculty

3. Gdansk University of Technology

4. 80-233 Gdansk

5. Poland

6. Department of Pharmaceutical Technology and Biochemistry

7. Faculty of Chemistry

Abstract

In the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA04957E

Reference34 articles.

1. Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

2. Preclinical antitumor activity of batracylin (NSC 320846)

3. Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia

4. Activity of batracylin (NSC-320846) against solid tumors of mice

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