Tuning a coiled-coil hydrogel via computational design of supramolecular fiber assembly

Author:

Britton Dustin1,Meleties Michael1,Liu Chengliang1,Jia Sihan1,Mahmoudinobar Farbod12ORCID,Renfrew P. Douglas2,Bonneau Richard234,Montclare Jin Kim1567ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA

2. Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, 10010, USA

3. Center for Genomics and Systems Biology, New York University, New York, New York, 10003, USA

4. Courant Institute of Mathematical Sciences, Computer Science Department, New York University, New York, New York, 10009, USA

5. Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA

6. Department of Chemistry, New York University, New York, New York, 10012, USA

7. Department of Biomaterials, New York University College of Dentistry, New York, New York, 10010, USA

Abstract

Higher-order supramolecular assembly of a coiled-coil protein can be modulated by iterative tuning of its electrostatic potential.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

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