Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity-Reference-Cited by-同舟云学术

Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity

Published:2021 Issue:9 Volume:12 Page:1585-1591
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pirrone Michael G.¹²³^ORCID,Hobbie Sven N.⁴^ORCID,Vasella Andrea⁵,Böttger Erik C.⁴,Crich David¹²⁶^ORCID

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA 30602, USA

2. Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA

3. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA

4. Institute of Medical Microbiology, University of Zurich, Gloriastrasse 28, 8006 Zürich, Switzerland

5. Organic Chemistry Laboratory, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland

6. Department of Chemistry, University of Georgia, 140 Cedar Street, Athens, GA 30602, USA

Abstract

Aminoglycosides with conformationally locked side chains and small hydrophobic patches show increased anti-bacterial activity and ribosomal selectivity. Fine tuning of side chain orientation indicates that the gt conformation is ideal for binding.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00214G

Reference44 articles.

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