Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe-Reference-Cited by-同舟云学术

Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe

Published:2021 Issue:11 Volume:12 Page:1935-1943
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Panyain Nattawadee¹^ORCID,Godinat Aurélien¹^ORCID,Thawani Aditya Raymond¹^ORCID,Lachiondo-Ortega Sofía¹^ORCID,Mason Katie²^ORCID,Elkhalifa Sarah²^ORCID,Smith Lisa M.²^ORCID,Harrigan Jeanine A.²^ORCID,Tate Edward W.¹³^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, UK

2. Mission Therapeutics Ltd, The Glenn Berge Building, Babraham Research Campus, Babraham, Cambridge, CB22 3FH, UK

3. The Francis Crick Institute, London, NW1 1AT, UK

Abstract

We report the characterization of a UCHL1 covalent inhibitor based on a thiazole cyanopyrrolidine scaffold and a closely-related activity-based probe (ABP) which was used to generate a quantitative profile for on- and off-targets in human cells.

Funder

Wellcome Trust

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Cancer Research UK

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00218J

Reference26 articles.