Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives-Reference-Cited by-同舟云学术

Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives

Published:2020 Issue:56 Volume:10 Page:34006-34013
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Hara Rintaro Iwata¹²³⁴⁵^ORCID,Yoshino Reijiro¹²³⁴,Nukaga Yohei¹²³⁴,Maeda Yusuke¹²³⁴,Sato Kazuki¹²³⁴,Wada Takeshi¹²³⁴^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Tokyo University of Science

3. Noda

4. Japan

5. Department of Neurology and Neurological Science

Abstract

The combination of 5-propynyluracil and (Rp)-PS linkages in a DNA strand could significantly increase the thermal stability of a DNA/RNA hybrid duplex.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06970A

Reference45 articles.

1. RNA-Targeted Therapeutics

2. Antisense technologies. Improvement through novel chemical modifications

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5. Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

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