Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

Author:

Xie Peng12345,Wang Yushu6789,Wei Dengshuai101112135,Zhang Lingpu101112135,Zhang Bin1415165,Xiao Haihua101112135ORCID,Song Haiqin1718192021,Mao Xinzhan12345

Affiliation:

1. Department of Orthopedics

2. The Second Xiangya Hospital

3. Central South University

4. Changsha

5. China

6. Department of Biomedical Engineering

7. Tufts University

8. Medford

9. USA

10. Beijing National Laboratory for Molecular Sciences

11. State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry

12. Chinese Academy of Sciences

13. Beijing 100190

14. XJTU-Oxford International Joint Laboratory for Catalysis

15. School of Chemical Engineering and Technology, Xi'an Jiaotong University

16. Xi'an

17. Department of General Surgery

18. Ruijin Hospital

19. Shanghai Jiao Tong University

20. School of Medicine

21. Shanghai 200025

Abstract

The mechanisms of chemoresistance and nanoparticle-based drug delivery systems for platinum drugs were detailed summarized in this review. The current combination therapy provided an effective strategy to overcome the platinum drug resistance.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Natural Science Foundation of Jiangxi Province

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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