pH/Thermosensitive dual-responsive hydrogel based sequential delivery for site-specific acute limb ischemia treatment

Author:

Zhang Teng12,Ouyang Huan3,Liu Shichen12,Xiong Lei2,Zhong Zhiwei1,Wang Qingqing2,Qiu Zhuang24,Ding Yajia2,Zhou Weimin1,Wang Xiaolei25ORCID

Affiliation:

1. Department of Vascular Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China

2. The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China

3. Department of Vascular and Thyroid Surgery, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230022, P. R. China

4. School of Public Health & Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang, Jiangxi, 330088, P. R. China

5. College of Chemistry, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China

Abstract

A nanoplatform was developed to respond the changes of two different phases of acute limb ischemia, sequential releasing of drugs thus could be realized automatically to achieve in time cytoprotective and angiogenesis effects.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Health Commission of Jiangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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