Development of a generic sample preparation method using dispersive liquid–liquid microextraction for the monitoring of leachable compounds in hospital pharmacy-prepared prefilled drug products

Author:

Bello William1234ORCID,Pezzatti Julian1ORCID,Rudaz Serge345,Sadeghipour Farshid1234

Affiliation:

1. Pharmacy Department, Lausanne University Hospital, Switzerland

2. Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital, University of Lausanne, Switzerland

3. School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211, Geneva 4, Switzerland

4. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Switzerland

5. Swiss Center of Applied Human Toxicology (SCATH), Basel, Switzerland

Abstract

Performant sample preparation is mandatory in any leachable study to clean and preconcentrate analytes within the sample to offer the best possible extraction recovery as well the best precision for any given substance.

Publisher

Royal Society of Chemistry (RSC)

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