A coelenterazine-type bioluminescent probe for nitroreductase imaging
Author:
Affiliation:
1. Department of Medicinal Chemistry
2. Key Laboratory of Chemical Biology (MOE)
3. School of Pharmacy
4. Shandong University
5. Jinan
Abstract
Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02618H
Reference39 articles.
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5. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts
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