Triazolopyrimidines identified as reversible myeloperoxidase inhibitors-Reference-Cited by-同舟云学术

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors

Published:2017 Issue:11 Volume:8 Page:2093-2099
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Duclos Franck¹²³^ORCID,Abell Lynn M.¹²³,Harden David G.¹²³,Pike Kristen¹²³,Nowak Kimberly¹²³,Locke Gregory A.¹²³,Duke Gerald J.¹²³,Liu Xiaoqin¹²³,Fernando Gayani¹²³,Shaw Scott A.¹²³,Vokits Benjamin P.¹²³,Wurtz Nicholas R.¹²³,Viet Andrew¹²³,Valente Meriah N.¹²³,Stachura Sylwia¹²³^ORCID,Sleph Paul¹²³,Khan Javed A.¹²³^ORCID,Gao Ji¹²³,Dongre Ashok R.¹²³,Zhao Lei¹²³,Wexler Ruth R.¹²³^ORCID,Gordon David A.¹²³,Kick Ellen K.¹²³^ORCID

Affiliation:

1. Bristol-Myers Squibb Company

2. Princeton

3. USA

Abstract

A novel myeloperoxidase inhibitor, 7-benzylether triazolopyrimidine was discovered which reversibly inhibits enzyme activity and shows pharmacodynamic effects in mouse models.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00268H

Reference34 articles.

1. Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

2. Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction

3. An abundant dysfunctional apolipoprotein A1 in human atheroma

4. Role of myeloperoxidase in cardiology

5. Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story;Journal of Medicinal Chemistry;2024-07-11

2. A Photoelectrochemical Sensor for the Detection of Hypochlorous Acid with a Phenothiazine-Based Photosensitizer;Molecules;2024-01-27

3. Optimization of ultrasound-assisted extraction of phenolic compounds from Populus nigra as potential myeloperoxidase inhibitors;Chemical Papers;2024-01-04

4. Therapeutic Strategies for Combating Reactive Oxygen Species in Cardiovascular Diseases;Oxidative Stress in Applied Basic Research and Clinical Practice;2024

5. Design, synthesis, and biological activity studies on benzimidazole derivatives targeting myeloperoxidase;European Journal of Medicinal Chemistry;2023-02