<i>N</i>-Cyano sulfilimine functional group as a nonclassical amide bond bioisostere in the design of a potent analogue to anthranilic diamide insecticide-Reference-Cited by-同舟云学术

N-Cyano sulfilimine functional group as a nonclassical amide bond bioisostere in the design of a potent analogue to anthranilic diamide insecticide

Published:2023 Issue:3 Volume:13 Page:2004-2009
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kang On-Yu¹²,Kim Eunsil¹³,Lee Won Hyung⁴,Ryu Do Hyun²^ORCID,Lim Hwan Jung¹⁵^ORCID,Park Seong Jun¹⁵^ORCID

Affiliation:

1. Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea

2. Department of Chemistry, Sungkyunkwan University, 2066 Seobu-ro, Suwon 16419, Republic of Korea

3. Department of Chemistry, Sogang University, 35 Baekbeom-ro, Seoul 04107, Republic of Korea

4. Central Research Institute, Kyung Nong Co. Ltd, 34-14 Summeori-gil, Kyongju 38175, Kyongsangbuk–do, Republic of Korea

5. Department of Medicinal Chemistry and Pharmacology, University of Science & Technology, 217 Gajeong-ro, Daejeon 34113, Republic of Korea

Abstract

To explore the potential of the N-cyano sulfilimine group as an amide bond isostere, a derivative of anthranilic diamide was synthesized and evaluated with regard to its physicochemical properties, permeability, and biological activity.

Funder

Korea Research Institute of Chemical Technology

Ministry of Science and ICT

Ministry of Trade, Industry and Energy

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D2RA06988A

Reference63 articles.

1. Bioisosterism: A Rational Approach in Drug Design

2. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

3. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

4. Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups

5. Simple strategy towards amide bioisosteres

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and Bioactivities of 5-Nitroimino-[1,4-2H]-1,2,4-triazolines as Olefin-Imidacloprid Mimics;Chinese Journal of Organic Chemistry;2023