Total synthesis of griseusins and elucidation of the griseusin mechanism of action-Reference-Cited by-同舟云学术

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Total synthesis of griseusins and elucidation of the griseusin mechanism of action

Published:2019 Issue:32 Volume:10 Page:7641-7648
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Yinan¹²³⁴⁵^ORCID,Ye Qing⁶⁷⁸⁹¹⁰,Ponomareva Larissa V.¹¹⁹¹⁰¹²¹³,Cao Yanan⁶⁷⁸⁹¹⁰,Liu Yang¹¹⁹¹⁰¹²¹³,Cui Zheng¹³⁹¹⁰¹²,Van Lanen Steven G.¹³⁹¹⁰¹²,Voss S. Randal¹⁴¹⁵¹⁶⁹¹⁰,She Qing-Bai⁶⁷⁸⁹¹⁰^ORCID,Thorson Jon S.¹¹⁹¹⁰¹²¹³^ORCID

Affiliation:

1. Jiangsu Key Laboratory for Functional Substances of Chinese Medicine

2. School of Pharmacy

3. Nanjing University of Chinese Medicine

4. Nanjing

5. China

6. Markey Cancer Center

7. Department of Pharmacology and Nutritional Sciences

8. College of Medicine

9. University of Kentucky

10. Lexington

11. Center for Pharmaceutical Research and Innovation

12. USA

13. College of Pharmacy

14. Department of Neuroscience

15. Spinal Cord and Brain Injury Research Center

16. Ambystoma Genetic Stock Center

Abstract

An efficient divergent synthesis of griseusins enabled SAR studies, mechanistic elucidation and evaluation in an axolotl tail regeneration model.

Funder

NIH Office of the Director

National Institute on Drug Abuse

National Center for Advancing Translational Sciences

National Natural Science Foundation of China

National Cancer Institute

University of Kentucky

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02289A

Reference69 articles.

1. Structure of frenolicin

2. Anticoccidial activity of frenolicin B and its derivatives.

3. Lactoquinomycin B, a novel antibiotic.

4. Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus

5. Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins

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