Facile solvolysis of a surprisingly twisted tertiary amide
Author:
Affiliation:
1. Department of Chemistry
2. Yale University
3. New Haven
4. USA
5. Energy Sciences Institute
6. West Haven
7. Yale School of Engineering and Applied Science
Abstract
A twisted 3° amide is cleaved at the same rate as a methyl ester under alkaline conditions at 22 °C.
Funder
National Science Foundation
Basic Energy Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2016/NJ/C5NJ02449H
Reference40 articles.
1. Studies on the Stability of Amides. I. Hydrolysis Mechanism of N-Substituted Aliphatic Amides
2. Amide bond formation and peptide coupling
3. Amide bond formation: beyond the myth of coupling reagents
4. Relationship between amidic distortion and ease of hydrolysis in base. If amidic resonance does not exist, then what accounts for the accelerated hydrolysis of distorted amides?
5. Distorted amides: correlation of their enhanced solvolysis with local charge depletions at the carbonyl carbon
Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. 2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring;Nature Communications;2023-10-02
2. Why Do N-Alkylated Anilides Bend Over? The Factors Dictating the Divergent Conformational Preferences of 2° and 3° N-Aryl Amides;The Journal of Physical Chemistry A;2019-08-13
3. Structure–function relationships in single molecule rectification by N-phenylbenzamide derivatives;New Journal of Chemistry;2016
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3