Increased block copolymer length improves intracellular availability of protein cargo-Reference-Cited by-同舟云学术

Increased block copolymer length improves intracellular availability of protein cargo

Published:2022 Issue:13 Volume:13 Page:1901-1910
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Hango Christopher R.¹^ORCID,Davis Hazel C.¹^ORCID,Uddin Esha A.¹,Minter Lisa M.²³^ORCID,Tew Gregory N.¹²³^ORCID

Affiliation:

1. Department of Polymer Science & Engineering, University of Massachusetts, Amherst, Amherst, Massachusetts 01003, USA

2. Molecular and Cellular Biology Program, University of Massachusetts, Amherst, Amherst, Massachusetts 01003, USA

3. Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003, USA

Abstract

Amphiphilic protein transduction domain mimics (PTDMs) of various lengths were used for protein delivery in Jurkat T cells. Although longer PTDMs facilitated greater cargo internalization, shorter PTDMs yielded greater cargo activity.

Funder

National Science Foundation

U.S. Department of Defense

University of Massachusetts Amherst

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/PY/D2PY00017B

Reference60 articles.

1. Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy

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5. Polymers for Protein Conjugation

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